Open AccessThe role of microRNAs in ovarian cancer initiation and progression
Author(s) -
Li ShuangDi,
Zhang JiaRong,
Wang YanQiu,
Wan XiaoPing
Publication year - 2010
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2010.01058.x
Subject(s) - microrna , ovarian cancer , carcinogenesis , epithelial ovarian cancer , biology , cancer , pathogenesis , cancer research , bioinformatics , oncology , medicine , immunology , gene , genetics
• Introduction • Aberrant expression of miRNAs in ovarian cancer • Regulation of microRNAs in ovarian cancer • Biological function of miRNAs in epithelial ovarian cancer ‐ Down‐regulation of let‐7: an early event during EOC initiation ‐ Multiple miRNAs as modulators of ovarian cancer cell proliferation ‐ miR‐199a and miR‐9: link between tumour progression and chronic inflammation ‐ HIF‐miR‐210 promotes cell adaptation during hypoxia ‐ miR‐200 is a dynamic regulator during the transcoelomic metastasis of EOC ‐ A proposed model for miRNA roles in ovarian cancer initiation and progression• miRNA as diagnostic and prognostic tools in ovarian cancer • Therapeutic potential of miRNAs in ovarian cancer • ConclusionsEpithelial ovarian cancer (EOC) has the highest mortality rate of all gynaecological cancers. One of the greatest impediments to improving outcome is an incomplete understanding of the molecular underpinnings of EOC pathogenesis and progression. Recent studies suggest that microRNAs (miRNAs) are involved in ovarian tumorigenesis and cancer development. Several miRNA profiling studies have identified some consensus aberrantly expressed miRNAs in EOC tissues, and these EOC‐related miRNAs may play critical roles in the pathogenesis and progression of EOC. Moreover, some of the miRNAs may have diagnostic or prognostic significance. In this review, recent progress to reveal the role of miRNAs in EOC will be addressed, and a model for miRNA functions in ovarian cancer initiation and progression will be proposed.