Open AccessBone regeneration: the stem/progenitor cells point of view
Author(s) -
Deschaseaux Frédéric,
Pontikoglou Charalampos,
Sensébé Luc
Publication year - 2010
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2009.00878.x
Subject(s) - progenitor cell , stem cell , microbiology and biotechnology , mesenchymal stem cell , regeneration (biology) , bone marrow , endothelial stem cell , stem cell transplantation for articular cartilage repair , progenitor , biology , clinical uses of mesenchymal stem cells , immunology , adult stem cell , in vitro , genetics
• Introduction • Mesenchymal stem cells as skeletal stem cells ‐ Cultured or expanded MSCs ‐ Native MSCs ‐ The neural crest origin of MSCs• Vascularization by endothelial progenitor cells as prerequisite process before bone repair ‐ Vascularization and bone healing ‐ Endothelial progenitor cells• ConclusionAfter bone injuries, several molecular mechanisms establish bone repair from stem/progenitor cells. Inflammation factors attract regenerative cells which expand and differentiate in order to build up a bone highly similar to that before injury. Bone marrow (BM) mesenchymal stem cells (MSCs) as skeletal stem cells and endothelial progenitors (EPCs) are at the origin of such reparation mechanisms. However, discrepancies exist about their identities. Although cultured MSCs are extensively described, their in vivo native forms are poorly known. In addition, recent experiments show that several types of EPC exist. We therefore review up‐to‐date data on the characterization of such stem/progenitor cells and propose a new point of view of their function in bone regeneration.