Open AccessThe ubiquitin‐proteasome system in cancer, a major player in DNA repair. Part 1: post‐translational regulation
Author(s) -
Vlachostergios Panagiotis J.,
Patrikidou Anna,
Daliani Danai D.,
Papandreou Christos N.
Publication year - 2009
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2009.00824.x
Subject(s) - ubiquitin , dna repair , proteasome , posttranslational modification , biology , microbiology and biotechnology , computational biology , dna , cancer research , genetics , biochemistry , gene , enzyme
• Introduction • Proteolytic roles of UPS in DNA repair ‐ MGMT repair pathway ‐ MMR pathway ‐ BER pathway ‐ NER pathway ‐ DSB repair pathway ‐ PRR pathway ‐ FA pathway• Non‐proteolytic roles of UPS in DNA repair ‐ FA pathway ‐ BER pathway ‐ DSB repair pathway ‐ PRR pathway ‐ NER pathway• Conclusive remarksDNA repair is a fundamental cellular function, indispensable for cell survival, especially in conditions of exposure to environmental or pharmacological effectors of DNA damage. The regulation of this function requires a flexible machinery to orchestrate the reversal of harmful DNA lesions by making use of existing proteins as well as inducible gene products. The accumulation of evidence for the involvement of ubiquitin‐proteasome system (UPS) in DNA repair pathways, that is reviewed here, has expanded its role from a cellular waste disposal basket to a multi‐dimensional regulatory system. This review is the first of two that attempt to illustrate the nature and interactions of all different DNA repair pathways where UPS is demonstrated to be involved, with special focus on cancer‐ and chemotherapy‐related DNA‐damage repair. In this first review, we will be presenting the proteolytic and non‐proteolytic roles of UPS in the post‐translational regulation of DNA repair proteins, while the second review will focus on the UPS‐dependent transcriptional response of DNA repair after DNA damage and stress.