Open Accessp27 Kip1 as a prognostic factor in breast cancer: a systematic review and meta‐analysis
Author(s) -
Guan Xiaoxiang,
Wang Yucai,
Xie Ruilian,
Chen Longbang,
Bai Jianling,
Lu Jia,
Kuo Macus Tien
Publication year - 2010
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2009.00730.x
Subject(s) - breast cancer , medicine , meta analysis , oncology , lymph node , overall survival , relative risk , cancer , confidence interval
Abstract The aim of this study was to comprehensively evaluate via a meta‐analysis the association between p27 expression and clinical outcome in breast cancer patients. We conducted a meta‐analysis of 20 studies ( n = 6463 patients) that evaluated the correlation between p27 expression and indicators of breast cancer clinical outcome, including overall survival (OS), disease‐free survival (DFS) and relapse‐free survival (RFS). Data pooling was performed by RevMan 4.2. A total of 60% (9 of 15) of the studies showed a significant association between p27 high expression and OS, whereas 25% (2 of 8) and 60% (3 of 5) studies demonstrated a correlation between p27 high expression and DFS and RFS, respectively. The relative risks (RRs) were 1.34 (1.26–1.42) for OS ( P < 0.00001), 1.27 (1.10–1.47) for DFS ( P = 0.001) and 1.49 (0.92–2.42) for RFS ( P = 0.10). In lymph node‐negative breast cancer patients, the RRs for OS and RFS were 1.84 (1.30–2.59; P = 0.0005) and 1.30 (0.20–8.50; P = 0.78), respectively. In lymph node‐positive breast cancer patients, the RRs for OS and RFS were 2.99 (1.77–5.07; P < 0.0001) and 1.49 (0.80–2.77; P = 0.21), respectively. This meta‐analysis indicates that reduced p27 is an independent prognostic factor for poor overall and disease‐free cancer survival.