Open AccessGlucuronoxylomannan promotes the generation of antigen‐specific T regulatory cell that suppresses the antigen‐specific Th2 response upon activation
Author(s) -
Liu Tao,
Chen Xiao,
Feng BaiSui,
He ShaoHeng,
Zhang TaoYuan,
Wang BinQuan,
Yang PingChang
Publication year - 2009
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2008.00583.x
Subject(s) - antigen , microbiology and biotechnology , immunology , biology , chemistry
T regulatory cells (Treg) have the capability to suppress the skewed immune response, but the generation of antigen (Ag)‐specific Treg for therapeutic purpose is a challenge; the mechanism of Ag‐specific Treg activation remains obscure. Here, we report that glucuronoxylomannan (GXM) is capable of promoting the development of human tolerogenic dendritic cells (DC). GXM‐pulsed DCs increased the expression of forkhead box P3 (Foxp3) in naïve human CD4 + CD25 − T cells via activating Fc γ receptor IIb and activator protein‐1 and promoting the expression of transforming growth factor β in dendritic cells. Furthermore, the conjugated complex of house dust mite Ag, Dermatophagoides pteronyssinus (Der p) 1, and GXM‐pulsed DCs to drive the naïve human CD4 + CD25 − T cells to develop into the Der p 1‐specific Tregs, which efficiently suppressed the Ag‐specific Th2 responses. We conclude that GXM‐conjugated specific Ag have the capacity to up‐regulate the tolerogenic property of DCs and promote the generation of Ag‐specific Tregs; the latter can be activated upon the re‐exposure to specific Ag and suppress the skewed Ag‐specific T helper (Th)2 responses.