Open AccessLet‐7 repression leads to HMGA2 overexpression in uterine leiomyosarcoma
Author(s) -
Shi Guizhi,
Perle Mary Ann,
Mittal Khush,
Chen Hua,
Zou Xuanyi,
Narita Masashi,
Hernando Eva,
Lee Peng,
Wei JianJun
Publication year - 2009
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2008.00541.x
Subject(s) - hmga2 , psychological repression , leiomyosarcoma , cancer research , chemistry , microbiology and biotechnology , medicine , biology , pathology , gene , gene expression , biochemistry , microrna
Overexpression of HMGA2 is common in uterine leiomyomas (ULM). The expression of HMGA2 in its malignant counterpart – uterine leiomyosarcomas (ULMS) remains undetermined. Recently it has been shown that repression of HMGA2 by microRNA let‐7s is a critical molecular regulatory mechanism associated with tumour growth in many tumours and cell types, including leiomyomas. To test whether HMGA2 and let‐7s play a role in ULMS, we examined the levels of endogenous HMGA2 and let‐7 expression and found a significant correlation between these two molecules in a case‐matched cohort of human ULMS. We found that overexpression of HMGA2 and let‐7 ‐mediated HMGA2 repression is a relevant molecular alteration in ULMS. Disrupting the control of HMGA2 and let‐7 pairs promotes ULMS cell growth in vitro .