Open AccessMesenchymal stem cells and cardiac repair
Author(s) -
Nesselmann Catharina,
Ma Nan,
Bieback Karen,
Wagner Wolfgang,
Ho Anthony,
Konttinen Yrjö T.,
Zhang Hao,
Hinescu Mihail E.,
Steinhoff Gustav
Publication year - 2008
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2008.00457.x
Subject(s) - mesenchymal stem cell , ex vivo , stem cell , mechanism (biology) , in vivo , cardiac cell , microbiology and biotechnology , medicine , cancer research , biology , bioinformatics , philosophy , epistemology
• Introduction • MSC isolation, characterization and standardization ‐ Isolation from different sources ‐ Isolation under different culture conditions ‐ Characterization of MSCs ‐ Standardization of MSCs• Mechanisms of cardiac repair ‐ Differentiation of MSCs towards cardiomyocytes ‐ Paracrine effect of MSCs ‐ MSCs and blood vessel regeneration ‐ MSC integration into the injured myocardium• Ex vivo manipulation of MSCs ‐ Pre‐treatment with growth factors ‐ Genetic engineering ‐ Hypoxia preconditioning ‐ Pharmacological interventions• Pre‐clinical application on cardiovascular disease • Clinical application: where are we? • SummaryAbstract Accumulating clinical and experimental evidence indicates that mesenchymal stem cells (MSCs) are promising cell types in the treatment of cardiac dysfunction. They may trigger production of reparative growth factors, replace damaged cells and create an environment that favours endogenous cardiac repair. However, identifying mechanisms which regulate the role of MSCs in cardiac repair is still at work. To achieve the maximal clinical benefits, ex vivo manipulation can further enhance MSC therapeutic potential. This review focuses on the mechanism of MSCs in cardiac repair, with emphasis on ex vivo manipulation.