Open AccessThe microRNAs involved in human myeloid differentiation and myelogenous/myeloblastic leukemia
Author(s) -
Wang XiaoShuang,
Zhang JunWu
Publication year - 2008
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2008.00386.x
Subject(s) - microrna , biology , myeloid leukemia , myeloid , epigenetics , haematopoiesis , regulation of gene expression , translation (biology) , leukemia , gene , cancer research , computational biology , genetics , messenger rna , stem cell
• Introduction • MiRNAs involved in myeloid differentiation may be involved in myeloid leukemia • MiRNAs directly involved in myeloid leukemia ‐ MiRNAs in acute myeloid leukemia ‐ MiRNAs in chronic myeloid leukemia ‐ Effective ATRA treatment of AML involves miRNA regulation• Regulation of miRNA expression ‐ Regulation of miRNA expression by transcription factors ‐ Epigenetic mechanisms silence miRNA expression ‐ Post‐transcriptional regulation of miRNA expression• Discussion and perspectivesAbstract MicroRNAs (miRNAs) are endogenously expressed, functional RNAs that interact with native coding mRNAs to cleave mRNA or repress translation. Several miRNAs contribute to normal haematopoietic processes and some miRNAs act both as tumour suppressors and oncogenes in the pathology of haematological malignancies. While most effort is engaged in identifying and investigating the target genes of miRNAs, miRNA gene promoter methylation or transcriptional regulation is another important field of investigation, since these two main mechanisms can form a regulatory circuit. This review focuses on recent researches on miRNAs with important roles in myeloid cells.