Open AccessDendritic cells as immune regulators: the mouse model
Author(s) -
Griffiths K.L.,
O’Neill H.C.
Publication year - 2008
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2008.00378.x
Subject(s) - immune system , immunology , biology , immune tolerance , antigen presentation , acquired immune system , context (archaeology) , immunity , inflammation , dendritic cell , microbiology and biotechnology , function (biology) , immunosuppression , central tolerance , antigen presenting cell , cross presentation , t cell , paleontology
• Introduction • The range of murine dendritic cell types • The tolerogenic function of dendritic cells • Regulatory dendritic cells and immunosuppression • The ubiquitous myeloid suppressor cells • What are regulatory dendritic cells?Abstract Dendritic cells (DC) are central to the immune system because of their role in antigen presentation leading to either tolerance or immunity among cells of the adaptive immune response. It is becoming increasingly evident that DC show extensive plasticity in terms of their origin and function, giving rise to a number of subsets represented differentially in all lymphoid organs. This article considers the tolerogenic capacity of murine DC and draws a distinction between DC that induce tolerance in the immature state and immunity in an inflammatory context, and those that act as regulatory cells inducing immunosuppression in the presence of inflammation.