Open AccessSystems biology approaches for the study of multiple sclerosis
Author(s) -
Quintana Francisco J.,
Farez Mauricio F.,
Weiner Howard L.
Publication year - 2008
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2008.00375.x
Subject(s) - proteomics , multiple sclerosis , genomics , metabolomics , disease , identification (biology) , computational biology , omics , biology , systems biology , bioinformatics , neuroscience , medicine , immunology , genome , genetics , pathology , gene , botany
• Introduction • Genomics • Transcriptomics ‐ Characterization of the MS lesion ‐ Characterization of the immune response• Proteomics ‐ Identification of new pathogenic processes ‐ Role of environmental triggers in MS ‐ Characterization of the autoimmune response: ‐ antibodies• Metabolomics • Integration of data from different ‘omics' approaches • New experimental models • ConclusionsAbstract Multiple sclerosis (MS) is a progressive neurological disease caused by an autoimmune attack to the central nervous system (CNS). MS is thought to result from a complex interaction between genetic and environmental factors. In this review, we analyse the contribution of genomics, trancriptomics and proteomics in delineating these factors, as well as their utility for the monitoring of disease progression, the identification of new targets for therapeutic intervention and the early detection of individuals at risk.