Open AccessA potential pathogenetic role of iron in Alzheimer's disease
Author(s) -
Silvestri Laura,
Camaschella Clara
Publication year - 2008
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2008.00356.x
Subject(s) - pathogenesis , furin , disease , alzheimer's disease , amyloid precursor protein , amyloid precursor protein secretase , amyloid (mycology) , neuroscience , p3 peptide , amyloid β , biochemistry of alzheimer's disease , biology , microbiology and biotechnology , medicine , biochemistry , immunology , pathology , enzyme
The role of iron in the pathogenesis of Alzheimer's disease (AD) is still unclear, despite the evidence that it accumulates in the same brain regions characterized by the amyloid β peptide (Aβ) accumulation. Here we propose that iron directly influences the A β production through the modulation of furin, a proconvertase involved in the regulation of the α‐secretase‐dependent processing of the amyloid protein precursor (APP).