Open AccessContributions of integrin‐linked kinase to breast cancer metastasis and tumourigenesis
Author(s) -
Hinton Cimona V.,
Avraham Shalom,
Avraham Hava Karsenty
Publication year - 2008
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2008.00300.x
Subject(s) - integrin linked kinase , cancer research , metastasis , breast cancer , protein kinase b , integrin , cancer , biology , metastatic breast cancer , angiogenesis , kinase , medicine , signal transduction , protein kinase a , microbiology and biotechnology , receptor , cyclin dependent kinase 2
• Introduction ‐ Role of integrins in tumourigenesis ‐ Role of integrins in signalling• Integrin‐linked kinase (ILK) ‐ ILK and binding complexes• ILK in breast cancer ‐ Regulation of ILK activity in breast cancer: growth factors, cytokines and tumour suppressors ‐ ILK: tumour suppressor?• VEGF‐ and HER2‐associated cross‐talks with ILK • Conclusion ‐ Molecular mechanisms of ILK in other tumoursAbstract Metastasis contributes to more than 90% of mortality in breast cancer. Critical stages in the development of aggressive breast cancer include growth of the primary tumours, and their abilities to spread to distant organs, colonize and establish an independent blood supply. The integrin family of cell adhesion receptors is essential to breast cancer progression. Furthermore, integrin‐linked kinase can ‘convert’ localized breast cancer cells into invasive and metastatic cells. Upon stimulation by growth factors and chemokine ligands, integrin‐linked kinase mediates the phosphorylation of Akt Ser 473 , and glycogen synthase kinase‐3. The current notion is that overexpression of integrin‐linked kinase resulted in an invasive, metastatic phenotype in several cancer model systems in vivo and in vitro , thus, implicating a role for integrin‐linked kinase in oncogenic transformation, angiogenesis and metastasis. Here, we will review the role of integrin‐linked kinase in breast cancer metastasis. Elucidation of signalling events important for breast tumour metastasis should provide insights into successful breast cancer therapies.