Open AccessCaveolae structure and function
Author(s) -
Thomas Candice M.,
Smart Eric J.
Publication year - 2008
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2008.00295.x
Subject(s) - caveolae , organelle , function (biology) , signalling pathways , microbiology and biotechnology , biology , signalling , computational biology , signal transduction
• Introduction • Lipid rafts and caveolae • Caveolin gene family • Polymerase I and transcript release factor (PTRF) • Cholesterol • Signal transduction • G‐protein coupled receptors • ENOS • Caveolae and disease • Prion diseases • Tumourigenesis • Animal models • Future directionAbstract Studies on the structure and function of caveolae have revealed how this versatile subcellular organelle can influence numerous signalling pathways. This brief review will discuss a few of the key features of caveolae as it relates to signalling and disease processes.