Open AccessTyrosine phosphorylation‐dependence of caveolae‐mediated endocytosis
Author(s) -
Sverdlov Maria,
Shajahan Ayesha N.,
Minshall Richard D.
Publication year - 2007
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2007.00127.x
Subject(s) - caveolae , endocytosis , transcytosis , microbiology and biotechnology , phosphorylation , endocytic cycle , biology , proto oncogene tyrosine protein kinase src , endosome , caveolin , tyrosine phosphorylation , signal transduction , biochemistry , intracellular , receptor
• Introduction • SRC signaling in caveolae‐mediated endocytosis • Potential role of SRC‐mediated phosphorylation of caveolin‐1 in caveolae‐mediated endocytosis • Role of actin cytoskeleton in caveolae‐mediated endocytosis • ConclusionAbstract Caveolae are flask‐shaped plasma membrane invaginations that mediate endocytosis and transcytosis of plasma macromolecules, such as albumin, insulin and low‐density lipoprotein (LDL), as well as certain viruses, bacteria and bacterial toxins. Caveolae‐mediated transcytosis of macromolecules is critical for maintaining vascular homeostasis by regulating the oncotic pressure gradient and tissue delivery of drugs, vitamins, lipids and ions. Entrapment of cargo within caveolae induces activation of signalling cascades leading to caveolae fission and internalization. Activation of Src tyrosine kinase is an early and essential step that triggers detachment of loaded caveolae from the plasma membrane. In this review, we examine how Srcmediated phosphorylation regulates caveolae‐mediated transport by orchestrating the localization and activity of essential proteins of the endocytic machinery to regulate caveolae formation and fission.