Open AccessEpigenetic boundaries of tumour suppressor gene promoters: the CTCF connection and its role in carcinogenesis
Author(s) -
RecillasTarga Felix,
RosaVelázquez Inti A.,
SotoReyes Ernesto,
BenítezBribiesca Luis
Publication year - 2006
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2006.tb00420.x
Subject(s) - epigenetics , ctcf , biology , epigenetic regulation of neurogenesis , carcinogenesis , dna methylation , genetics , histone , cancer epigenetics , regulator , epigenetics of physical exercise , epigenesis , microbiology and biotechnology , gene , computational biology , transcription factor , gene expression , histone methyltransferase , enhancer
Genetic and epigenetic regulations are essential mechanisms that ensure proper early and subsequent mammalian programming of diverse cellular processes. These mechanisms affect transcriptional regulation, stem cell determination and cell cycle control, including senescence and aging. It is not surprising that perturbation of the exquisite balance between genetic and epigenetic regulation can lead to diverse diseases, including cancer. Histone covalent modifications and DNA methylation do not explain all epigenetic phenomena. We describe a previously unsuspected epigenetic factor and propose the incorporation of the 11‐zinc finger CCCTC‐binding factor, known as CTCF as a novel and multifunctional epigenetic regulator.