Open AccessPathways of apoptosis and importance in developement
Author(s) -
Twomey Ciara,
McCarthy J. V.
Publication year - 2005
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2005.tb00360.x
Subject(s) - programmed cell death , multicellular organism , biology , microbiology and biotechnology , apoptosis , caenorhabditis elegans , cell , cell fate determination , cell growth , genetics , gene , transcription factor
Abstract The elimination of cells by programmed cell death is a fundamental even in developmental event in development where multicellular ogranisms regulate cell numbers or eliminate cells that are functional reduandant or potentially detrimental to the ogranism. The evolutionary conservation of the biochemical and genetic regulating of programmed cell death across species has allowed the genetic pathyways of programmed cell death determined in lower species, such as the nematode Caenorhabditis elegans and the fruitfly Dorsophila melangaster to act as models to delineate the genetics and regulation of cell death in mammalian cells. These studies have identified cell autonomous and non‐autonomous mechanisms that regulate of cell death and reveal that developmental cell death can either be a pre‐determined cell fate or the consequence of insufficient cell interactions that normally promote cell survival.