Open AccessNeural stem cells in inflammatory CNS diseases: mechanisms and therapy
Author(s) -
Magnus T.,
Rao M. S.
Publication year - 2005
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2005.tb00357.x
Subject(s) - central nervous system , neuroscience , immune system , endogeny , immunology , stem cell , neural stem cell , pathogenesis , biology , inflammation , focus (optics) , medicine , microbiology and biotechnology , endocrinology , physics , optics
Autoimmune inflammatory diseases of the central nervous system (CNS) are highly complex in their interaction of different cell populations. The main therapy focus in the last years has been the inhibition of the immune system. Recent progress has shown that endogenous as well as transplanted neural stem cells might positively influence the outcome of such diseases. In this review, we discuss the current concept of the underlying pathogenesis with a specific focus on local CNS cells and potential treatment options.