Open AccessEngineering bone: challenges and obstacles
Author(s) -
LogeartAvramoglou D.,
Anagnostou F.,
Bizios R.,
Petite H.
Publication year - 2005
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2005.tb00338.x
Subject(s) - scaffold , induced pluripotent stem cell , stem cell , tissue engineering , computer science , medicine , biomedical engineering , biology , embryonic stem cell , microbiology and biotechnology , biochemistry , gene
Repair of large bone defects is still a challenge for the orthopaedic, reconstructive and maxillo‐facial surgeon. Availability of pluripotent stem cells from either autologous or allogenic sources and the potential of inducing the osteogenic phenotype is motivating exploration and development of custom‐tailored materials known as “bioengineered bone constructs”. In such cases, the clinical scenario involves either expansion of stem cells in monolayer and loading them into a porous scaffold prior to surgery or direct cell expansion within the scaffold, and implanting this novel construct back into the donor patient. In this review, we delineate, from an engineering perspective, the progress that has been made to date and the challenges remaining in successfully translating this promising (but not yet definitively established) approach from bench to the bedsite.