Open AccessIntracellular calcium signals and control of cell proliferation: how many mechanisms?
Author(s) -
Munaron L.,
Antoniotti S.,
Lovisolo D.
Publication year - 2004
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2004.tb00271.x
Subject(s) - second messenger system , extracellular , intracellular , cytosol , microbiology and biotechnology , calcium , calcium in biology , calcium signaling , signal transduction , biology , cell , chemistry , biochemistry , enzyme , organic chemistry
The progression through the cell cycle in non‐transformed cells is under the strict control of extracellular signals called mitogens, that act by eliciting complex cascades of intracellular messengers. Among them, increases in cytosolic free calcium concentration have been long realized to play a crucial role; however, the mechanisms coupling membrane receptor activation to calcium signals are still only partially understood, as are the pathways of calcium entry in the cytosol. This article centers on the role of calcium influx from the extracellular medium in the control of proliferative processes, and reviews the current understanding of the pathways responsible for this influx and of the second messengers involved in their activation.