Open AccessGenetic clock of biologic rhythms
Author(s) -
Badiu C.
Publication year - 2003
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2003.tb00243.x
Subject(s) - clockwork , oscillating gene , clock , biology , circadian clock , gene , circadian rhythm , bacterial circadian rhythms , microbiology and biotechnology , transcription (linguistics) , timeless , biological clock , genetics , rhythm , neuroscience , medicine , physics , philosophy , astronomy , linguistics
Biologic rhythms are tighly regulated in all species, in order to addapt to circadian variations of light, temperature and other biological related living conditions. The intrinsic mechanisms of rhythm regulation from every cell to a whole organism is embedded into the genetic clockwork. The mammalian clock genes are reviewed with their interrelation. The per gene promoter is stimulated by clock/bmall heterodimer and trigger the per protoeins synthesis. Innitialy considered as a simple negative feed‐back, from to the phosphorylated per/cry heterodimer towards clock/bmall transcription stimulus, the clockweb of the cell became complex. General characteristics of cell clock genes are integrated in a model. In addition, the involvement of clock genes in peripheral tissues is discussed.