Open AccessAkt and PTEN: New diagnostic markers of non‐small cell lung cancer?
Author(s) -
David Odile
Publication year - 2001
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2001.tb00178.x
Subject(s) - pten , protein kinase b , cancer research , pi3k/akt/mtor pathway , tumor suppressor gene , lung cancer , biology , cell growth , cancer , signal transduction , medicine , pathology , carcinogenesis , microbiology and biotechnology , genetics
We are particularly interested in testing the principles of cell proliferation and apoptosis in the microenvironment of human lung cancers with respect to the cell survival protein Akt 1 and PTEN 2 . Akt is a cytosolic protein which promotes cell survival by phosphorylative inactivation of targets in apoptotic pathways. Akt has been found to play a role in the survival of experimental cancer cell lines in breast, prostate, ovary, lung and brain tissue. PTEN is a tumor suppressor gene whose protein product is expressed in inverse proportion to phosphorylated Akt in endometrial and breast cancer cell lines. No studies of the diagnostic significance of Akt and PTEN in human lung cancers have been reported.