Open AccessFibroblast growth factors in myocardial ischemia / reperfusion injury and ischemic preconditioning
Author(s) -
Cuevas P.,
Carceller F.,
GiménezGallego G.
Publication year - 2001
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2001.tb00146.x
Subject(s) - fibroblast growth factor , myocardial infarction , medicine , ischemia , ischemic preconditioning , cardiology , myocardial ischemia , pharmacology , receptor
Angiogenic growth factors such as fibroblast growth factors (FGFs) are currently in clinical trials for accelerating blood vessel formation in myocardial and limb ischemic conditions. However, recent experimental evidence suggests that FGFs can also participate as endogenous cardioprotective agents. In this report, the current knowledge for FGFs implication in myocardial ischemic tolerance will be summarized. Pharmacologic preconditioning with drugs as FGFs that mimic the beneficial effects of ischemic preconditioning could lead to novel therapeutic approaches for the treatment of ischemic disorders including myocardial infarction and stroke.