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Toxicity of the fungal metabolite griseofulvin to Helicoverpa zea and Spodoptera frugiperda
Author(s) -
Dowd Patrick F.
Publication year - 1993
Publication title -
entomologia experimentalis et applicata
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.765
H-Index - 83
eISSN - 1570-7458
pISSN - 0013-8703
DOI - 10.1111/j.1570-7458.1993.tb01722.x
Subject(s) - griseofulvin , piperonyl butoxide , spodoptera , helicoverpa zea , biology , toxicity , metabolite , fall armyworm , biochemistry , botany , noctuidae , lepidoptera genitalia , chemistry , agronomy , pesticide , medicine , organic chemistry , pathology , gene , recombinant dna
Abstract Griseofulvin is a fungal metabolite that can be considered a mycotoxin but is used pharmaceutically to treat topical fungal infections. It was found to be toxic to both the corn earworm. Helicoverpa zea Boddie, and the fall armyworm, Spodoptera frugiperda (J. E. Smith), at 250 ppm in diets. Its toxicity was enhanced by exposure to ultraviolet light, suggesting it can be photoactivated. Its toxicity was also enhanced by coincorporated δ‐amino levulinic acid, suggesting it interferes with porphyrin synthesis in these insects. Differences in toxicity and rates of metabolism caused by coincorporated piperonyl butoxide suggested unspecific monooxygenases were relatively more important in griseofulvin activation in H. zea and detoxification in S. frugiperda.