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THE ADAPTATION RATE OF ASEXUALS: DELETERIOUS MUTATIONS, CLONAL INTERFERENCE AND POPULATION BOTTLENECKS
Author(s) -
Campos Paulo R. A.,
Wahl Lindi M.
Publication year - 2010
Publication title -
evolution
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.84
H-Index - 199
eISSN - 1558-5646
pISSN - 0014-3820
DOI - 10.1111/j.1558-5646.2010.00981.x
Subject(s) - biology , mutation rate , adaptation (eye) , population , interference (communication) , experimental evolution , mutation , genetics , evolutionary biology , population size , gene , computer science , computer network , channel (broadcasting) , demography , neuroscience , sociology
The rate at which a population adapts to its environment is a cornerstone of evolutionary theory, and recent experimental advances in microbial populations have renewed interest in predicting and testing this rate. Efforts to understand the adaptation rate theoretically are complicated by high mutation rates, to both beneficial and deleterious mutations, and by the fact that beneficial mutations compete with each other in asexual populations (clonal interference). Testable predictions must also include the effects of population bottlenecks, repeated reductions in population size imposed by the experimental protocol. In this contribution, we integrate previous work that addresses each of these issues, developing an overall prediction for the adaptation rate that includes: beneficial mutations with probabilistically distributed effects, deleterious mutations of arbitrary effect, population bottlenecks, and clonal interference.