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DNA Typing for the Identification of Old Skeletal Remains from Korean War Victims *
Author(s) -
Lee Hwan Young,
Kim Na Young,
Park Myung Jin,
Sim Jeong Eun,
Yang Woo Ick,
Shin KyoungJin
Publication year - 2010
Publication title -
journal of forensic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.715
H-Index - 96
eISSN - 1556-4029
pISSN - 0022-1198
DOI - 10.1111/j.1556-4029.2010.01411.x
Subject(s) - mitochondrial dna , genotyping , dna profiling , microsatellite , genetics , biology , identification (biology) , forensic identification , amplicon , dna extraction , circumstantial evidence , typing , dna , evolutionary biology , polymerase chain reaction , computational biology , genotype , allele , history , gene , archaeology , botany
The identification of missing casualties of the Korean War (1950–1953) has been performed using mitochondrial DNA (mtDNA) profiles, but recent advances in DNA extraction techniques and approaches using smaller amplicons have significantly increased the possibility of obtaining DNA profiles from highly degraded skeletal remains. Therefore, 21 skeletal remains of Korean War victims and 24 samples from biological relatives of the supposed victims were selected based on circumstantial evidence and/or mtDNA‐matching results and were analyzed to confirm the alleged relationship. Cumulative likelihood ratios were obtained from autosomal short tandem repeat, Y‐chromosomal STR, and mtDNA‐genotyping results, and mainly confirmed the alleged relationship with values over 10 5 . The present analysis emphasizes the value of mini‐ and Y‐STR systems as well as an efficient DNA extraction method in DNA testing for the identification of old skeletal remains.