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Predicting Phenotype from Genotype: Normal Pigmentation *
Author(s) -
Valenzuela Robert K.,
Henderson Miquia S.,
Walsh Monica H.,
Garrison Nanibaa’ A.,
Kelch Jessica T.,
CohenBarak Orit,
Erickson Drew T.,
John Meaney F.,
Bruce Walsh J.,
Cheng Keith C.,
Ito Shosuke,
Wakamatsu Kazumasa,
Frudakis Tony,
Thomas Matthew,
Brilliant Murray H.
Publication year - 2010
Publication title -
journal of forensic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.715
H-Index - 96
eISSN - 1556-4029
pISSN - 0022-1198
DOI - 10.1111/j.1556-4029.2009.01317.x
Subject(s) - genetics , single nucleotide polymorphism , biology , genotype , locus (genetics) , population , phenotype , gene , evolutionary biology , medicine , environmental health
Genetic information in forensic studies is largely limited to CODIS data and the ability to match samples and assign them to an individual. However, there are circumstances, in which a given DNA sample does not match anyone in the CODIS database, and no other information about the donor is available. In this study, we determined 75 SNPs in 24 genes (previously implicated in human or animal pigmentation studies) for the analysis of single‐ and multi‐locus associations with hair, skin, and eye color in 789 individuals of various ethnic backgrounds. Using multiple linear regression modeling, five SNPs in five genes were found to account for large proportions of pigmentation variation in hair, skin, and eyes in our across‐population analyses. Thus, these models may be of predictive value to determine an individual’s pigmentation type from a forensic sample, independent of ethnic origin.