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Octylcyanoacrylate for the Treatment of Contaminated Partial‐thickness Burns in Swine A Randomized Controlled Experiment
Author(s) -
Singer Adam J.,
Mohammad Mazhar,
Tortora George,
Thode Henry C.,
McClain Steve A.
Publication year - 2000
Publication title -
academic emergency medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.221
H-Index - 124
eISSN - 1553-2712
pISSN - 1069-6563
DOI - 10.1111/j.1553-2712.2000.tb01063.x
Subject(s) - medicine , silver sulfadiazine , surgery , nuclear medicine , wound healing
Objective: To compare infection and reepithelialization rates of contaminated second‐degree burns treated with octylcyanoacrylate (OCA), silver sulfadiazine (SSD), polyurethane (PU) film, and dry gauze (control; C) in swine. Methods: Eighty standardized burns were created by applying an aluminum bar preheated to 80°C to the backs and flanks of young pigs for 20 seconds. All burns were immediately contaminated with 0.1 mL of Staphylococcus aureus 10 5 /mL and randomly treated with OCA spray, SSD, PU, or dry gauze (C). Full‐thickness biopsies were taken at 3, 7, and 14 days for blinded histopathologic evaluation using hematoxylin and eosin (H&E)‐stained slides. Burns were considered infected in the presence of interstitial reticular dermal neutrophils containing bacteria (intraobserver agreement, κ= 1.00). Quantitative wound cultures were performed on a second day‐3 specimen. Results: At day 3, wound infection rates were 30% (OCA), 50% (SSD), 55% (PU), and 50% (C); p = 0.40 (Kruskal‐Wallis test). At day 7, infection rates were 35% (OCA), 85% (SSD), 70% (PU), and 65% (C); p = 0.01. Median bacterial counts at day 3 were 6,500 (OCA), 20,000 (SSD), 1,000,000 (PU), and 650,000 (C); p = 0.29. The proportion of completely reepithelialized wounds at day 14 were 75% (OCA), 90% (SSD), 85% (PU), and 90% (C); p = 0.50. Conclusions: Treatment of contaminated partial‐thickness burns with OCA spray resulted in fewer infections at one week than with the other three treatments.