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Amrinone as an Antidote in Experimental Veraparnil Overdose
Author(s) -
Koury Shaheed I.,
Stone C. Keith,
Thomas Stephen H.
Publication year - 1996
Publication title -
academic emergency medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.221
H-Index - 124
eISSN - 1553-2712
pISSN - 1069-6563
DOI - 10.1111/j.1553-2712.1996.tb03512.x
Subject(s) - medicine , antidote , amrinone , intensive care medicine , emergency medicine , medical emergency , anesthesia , hemodynamics , toxicity
Objective: To evaluate the effect of amrinone as a treatment for the hemodynamic effects of verapamil overdose in a canine model. Methods: This nonblind interventional study was performed in an established canine model of verapamil toxicity, without concurrent control animals. Pentobarbital‐anesthetized and instrumented dogs ( n = 8) were maintained and observed for 60 minutes or until death. The animals were overdosed with verapamil, 15 mg/kg IV, over 30 minutes. Hemodynamic parameters, including cardiac index (CI), heart rate (HR), and mean arterial pressure (MAP), were monitored. Completion of the verapamil infusion represented the defined point of toxicity; at that point, all the animals received an amrinone bolus of 2 mgkg IV over 2 minutes followed by an amrinone drip at 10 μg/kg/min. The hemodynamic values at the defined point of toxicity were compared with those obtained postinitiation of the amrinone infusion. Conclusion: Amrinone appears to reverse the depressed cardiac index associated with verapamil overdose in a canine model while having no significant effect on the hypotension or bradycardia.