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Microvascular Imaging in Acute Ischemic Stroke
Author(s) -
Seidel Günter,
Roessler Florian,
AlKhaled Mohamed
Publication year - 2013
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/j.1552-6569.2012.00712.x
Subject(s) - medicine , perfusion , perfusion scanning , ultrasound , radiology , stroke (engine) , internal carotid artery , occlusion , bolus (digestion) , cardiology , nuclear medicine , mechanical engineering , engineering
BACKGROUND Microvascular imaging (MVI), a new ultrasound technology, is used to analyze brain perfusion at the patient's bedside. This study aims to evaluate the diagnostic and prognostic value of MVI in patients with acute ischemic stroke (AIS). METHODS Nineteen patients suffering from AIS (mean age, 70.9 ± 12.2 years; 47% female; mean NIHSS‐score, 12 ± 8) were investigated within the first 12 hours after symptom onset. We used the iU22 (Philips) system (S5–1 probe; low‐mechanical index; depth, 13 cm), and 2 bolus injections of an ultrasound contrast agent (2.4 mL SonoVue™ per injection). The area of maximal perfusion deficit (AMPD) was compared with infarction on follow‐up cranial computed tomography (CT) and NIHSS score 24 hours after stroke onset. RESULTS Of 19 patients, 15 patients (79%) had sufficient insonation conditions. Of these patients, 12 had infarctions. The sensitivity and specificity of detecting infarctions with ultrasound perfusion imaging were 91% and 67%, respectively. A significant correlation existed between the AMPD and NIHSS score at 24 hours after symptom onset ( P = .023), and with occlusion of the internal carotid artery ( P = .005). CONCLUSION Performing bedside MVI in the early phase of AIS provides information on brain parenchyma perfusion and prognosis of AIS.