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High b ‐Value q ‐Space Analyzed Diffusion‐Weighted MRI Using 1.5 Tesla Clinical Scanner; Determination of Displacement Parameters in the Brains of Normal versus Multiple Sclerosis and Low‐Grade Glioma Subjects
Author(s) -
Fatima Zareen,
Motosugi Utaroh,
Hori Masaaki,
Ishigame Keiichi,
Onodera Toshiyuki,
Yagi Kazuo,
Araki Tsutomu
Publication year - 2012
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/j.1552-6569.2011.00596.x
Subject(s) - medicine , multiple sclerosis , white matter , nuclear medicine , diffusion mri , cerebrospinal fluid , glioma , magnetic resonance imaging , pathology , ventricle , radiology , cancer research , psychiatry
PURPOSE We aimed to determine the displacement parameters in the brains of normal individuals relative to brain parenchymal abnormalities, such as multiple sclerosis (MS) and low‐grade glioma, by q ‐space imaging (QSI) using 1.5‐T magnetic resonance (MR) scanner.MATERIALS AND METHODS Thirty‐five normal, three pathologically proven low‐grade glioma, and five MS subjects were imaged by a 1.5‐T MR unit for QSI ( b ‐values, 0‐12,000 s/mm 2 ). Mean displacement (MD) values in white matter (WM), gray matter (GM), and lateral ventricle (cerebrospinal fluid [CSF]) of normal subjects, plaques, and normal appearing WM (NAWM) of MS subjects and glioma lesions were calculated. Mann‐Whitney U test was used for comparison.RESULTS In normal subjects, MD values were 6.6 ± 0.2, 8.44 ± 0.41, and 17.08 ± 0.80 μm for WM, GM, and CSF, respectively, while those for NAWM and WM plaques in MS, and glioma lesions were significantly higher at 7.0 ± 0.17, 9.3 ± 2.3, and 9.6 ± 0.40 μm, respectively, compared to WM in normal subjects.CONCLUSION We propose that the relative values of MD obtained by QSI in control and diseased tissues can be useful for diagnosing various WM abnormalities.