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Reliability of the ABC/2 Method in Determining Acute Infarct Volume
Author(s) -
Pedraza Salvador,
Puig Josep,
Blasco Gerard,
DaunisiEstadella Josep,
Boada Imma,
Bardera Anton,
Castellanos Mar,
Serena Joaquín
Publication year - 2012
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/j.1552-6569.2011.00588.x
Subject(s) - medicine , volume (thermodynamics) , reproducibility , reliability (semiconductor) , intraclass correlation , gold standard (test) , inter rater reliability , nuclear medicine , acute stroke , stroke (engine) , radiology , statistics , mathematics , mechanical engineering , power (physics) , physics , rating scale , quantum mechanics , tissue plasminogen activator , engineering , clinical psychology , psychometrics
BACKGROUND AND PURPOSE Infarct volume is used as a surrogate outcome measure in clinical trials of therapies for acute ischemic stroke. ABC/2 is a fast volumetric method, but its accuracy remains to be determined. We aimed to study the accuracy and reproducibility of ABC/2 in determining acute infarct volume with diffusion‐weighted imaging.METHODS We studied 86 consecutive patients with acute ischemic stroke. Three blinded observers determined volume with the ABC/2 method, and the results were compared with those of the manual planimetric method.RESULTS The ABC/2 technique overestimated infarct volume by a median false increase (variable ABC/2 volume minus planimetric volume) of 7.33 cm 3 (1.29, 22.170, representing a 162.56% increase over the value of the gold standard (variable ABC/2 volume over planimetric volume) (121.70, 248.52). In each method, the interrater reliability was excellent: the intraclass correlations were .992 and .985 for the ABC/2 technique and planimetric method, respectively.CONCLUSIONS ABC/2 is volumetric method with clinical value but it consistently overestimates the real infarct volume. J Neuroimaging 2012;22:155‐159