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Comparison of Proton Magnetic Resonance Spectroscopy with Fluorine‐18 2‐Fluoro‐Deoxyglucose Positron Emission Tomography for Assessment of Brain Tumor Progression
Author(s) -
Imani Farzin,
Boada Fernando E.,
Lieberman Frank S.,
Davis Denise K.,
Deeb Erin L.,
Mountz James M.
Publication year - 2012
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/j.1552-6569.2010.00561.x
Subject(s) - medicine , positron emission tomography , nuclear medicine , glioma , magnetic resonance imaging , grading (engineering) , brain tumor , proton magnetic resonance , radiology , pathology , nuclear magnetic resonance , cancer research , civil engineering , physics , engineering
OBJECTIVES We investigated the accuracy of high‐field proton magnetic resonance spectroscopy ( 1 H MRS) and fluorine‐18 2‐fluoro‐deoxyglucose positron emission tomography ( 18 F‐FDG‐PET) for diagnosis of glioma progression following tumor resection, stereotactic radiation, and chemotherapy. METHODS Twelve post‐therapy patients with histology proven gliomas (six grade II and six grade III) presented with magnetic resonance imaging (MRI) and clinical symptoms suggestive but not conclusive of progression were entered into the study. 1 H MRS data were acquired and 3‐dimensional volumetric maps of choline (Cho) over creatine (Cr) were generated. Intensity of 18 F‐FDG uptake was evaluated on a semiquantitative scale. RESULTS The accuracy of 1 H MRS and 18 F‐FDG‐PET imaging for diagnosis of glioma progression was 75% and 83%, respectively. Classifying the tumors by grade improved accuracy of 18 F‐FDG‐PET to 100% in high‐grade gliomas and accuracy of 1 H MRS to 80% in low‐grade tumors. Spearman's analysis demonstrated a trend between 18 F‐FDG uptake and tumor grading (ρ= .612, P ‐value = .272). The results of 18 F‐FDG‐PET and 1 H MRS were concordant in 75% (9/12) of cases. CONCLUSION The combination of 1 H MRS data and 18 F‐FDG‐PET imaging can enhance detection of glioma progression. 1 H MRS imaging was more accurate in low‐grade gliomas and 18 F‐FDG‐PET provided better accuracy in high‐grade gliomas. J Neuroimaging 2012;22:184‐190