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Which SPM Method Should Be Used to Extract Hippocampal Measures in Early Alzheimer's Disease?
Author(s) -
Mevel Katell,
Desgranges Béatrice,
Baron JeanClaude,
Landeau Brigitte,
de La Sayette Vincent,
Viader Fausto,
Eustache Francis,
Chételat Gaël
Publication year - 2011
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/j.1552-6569.2010.00548.x
Subject(s) - atrophy , region of interest , medicine , hippocampal formation , neuroimaging , gold standard (test) , alzheimer's disease , voxel , cognitive impairment , alzheimer's disease neuroimaging initiative , artificial intelligence , pathology , radiology , disease , computer science , psychiatry
BACKGROUND AND PURPOSE To provide guidance regarding the most appropriate voxel‐based morphometry (VBM)‐derived method for assessing hippocampal atrophy in early Alzheimer's disease (AD).METHODS T1‐MRI volume data were collected in 23 patients with amnestic mild cognitive impairment (aMCI) and 18 controls. Three types of data (unmodulated and 2 types of modulated MRI) and 2 extraction methods (with reference to the hippocampal peak of atrophy identified from a preliminary whole‐brain analysis, or using a template region of interest–ROI–approach) were compared to the gold‐standard individual ROI (ROI‐i) method through 2 statistical approaches (ANOVA and Pearson's R).RESULTS First, whole‐brain analyses performed on modulated data are as sensitive as the ROI‐i approach in detecting aMCI patients’ hippocampal atrophy. Second, values extracted from the ROI‐template applied to modulated data provide measures of hippocampal volume comparable to those obtained using the ROI‐i approach.CONCLUSIONS This study provides guidance on how to extract accurate hippocampal measures from VBM‐derived data in early AD, as a time‐saving and easy alternative to the reference ROI‐i method. J Neuroimaging 2011;21:310‐316.