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Quality and Quantity of Diffuse and Focal White Matter Disease and Cognitive Disability of Patients with Multiple Sclerosis
Author(s) -
Bomboi Giuseppe,
Ikonomidou Vasiliki N.,
Pellegrini Stefano,
Stern Susan K.,
Gallo Antonio,
Auh Sungyoung,
Evangelou Iordanis E.,
Agarwal Jhalak,
Pellicano Clelia,
Ohayon Joan M.,
Cantor Fredric K.,
Ehrmantraut Mary,
McFarland Henry F.,
Kane Robert L.,
Bagnato Francesca
Publication year - 2011
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/j.1552-6569.2010.00488.x
Subject(s) - medicine , multiple sclerosis , white matter , expanded disability status scale , hyperintensity , magnetic resonance imaging , depression (economics) , verbal learning , california verbal learning test , cohort , lesion , cognition , audiology , nuclear medicine , cardiology , radiology , pathology , psychiatry , macroeconomics , economics
BACKGROUND AND PURPOSE Using high‐field magnetic resonance imaging (MRI), we investigated the relationships between white matter (WM) lesion volume (LV), normal‐appearing WM (NAWM) normalized volume, WM‐lesion and NAWM magnetization transfer ratios (MTRs), brain parenchyma fraction (BPF), and cognitive impairment (CI) in multiple sclerosis (MS).METHODS Twenty‐four patients and 24 healthy volunteers (age, sex, and years of education–matched) underwent a 3.0 Tesla (3T) scan and evaluation of depression, fatigue, and CI using the Minimal Assessment of Cognitive Function in MS (MACFIMS) battery.RESULTS In this clinically relatively well‐preserved cohort of patients (median score on the Expanded Disability Status Scale = 1.5), CI was detected on Symbol Digit Modalities Test (SDMT), California Verbal Learning Test‐II (CVLT‐II), and Controlled Oral Word Association Test. MT data were available in 19 pairs on whom correlation analyses were performed. Associations were seen between SDMT and normalized NAWM volume ( P = .034, r = .502), CVLT‐II long delay and normalized NAWM volume ( P = .012, r = .563), WM‐LV ( P = .024, r = .514), and BPF ( P = .002, r = .666).CONCLUSIONS The use of 3T MRI in a sample of clinically stable MS patients shows the importance of WM disease in hampering processing speed and word retrieval.