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Vasomotor Reactivity Is Similarly Impaired in Patients with Alzheimer's Disease and Patients with Amyloid Hemorrhage
Author(s) -
MenendezGonzalez Manuel,
GarciaGarcia Jorge,
Calleja Sergio,
Rojo Jose,
Ribacoba Renee
Publication year - 2011
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/j.1552-6569.2009.00438.x
Subject(s) - medicine , cerebral amyloid angiopathy , vasomotor , disease , alzheimer's disease , amyloid (mycology) , transcranial doppler , pathology , cardiology , dementia
Cerebral amyloid angiopathy (CAA) might alter cerebral hemodynamics. Impairment of vasomotor reactivity may constitute a biomarker of amyloid angiopathy and therefore it may be useful to distinguish disorders with CAA from other conditions. The aim of this study was to assess the vasomotor reactivity in two conditions characterized by CAA: Alzheimer's disease and amyloid hemorrhage.METHODS We assessed the vasomotor using transcranial Doppler and the breath‐holding method.RESULTS Responses obtained in controls were higher than in patients with Alzheimer's or with antecedent of amyloid hemorrhage while there was no statistical difference in the comparison between these last two groups.CONCLUSION The vasomotor reactivity seems to be similarly impaired in Alzheimer's disease and amyloid hemorrhage patients.