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Isolated and Reversible Lesions of the Corpus Callosum: A Distinct Entity
Author(s) -
GarciaMonco Juan Carlos,
Martínez Amaia,
Brochado Ana Pinedo,
Saralegui Ibone,
Cabrera Alberto,
Beldarrain Marian Gomez
Publication year - 2010
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/j.1552-6569.2009.00427.x
Subject(s) - splenium , medicine , fluid attenuated inversion recovery , corpus callosum , magnetic resonance imaging , lesion , cerebral edema , edema , pathology , neuroimaging , encephalopathy , radiology , diffusion mri , psychiatry
The Reversible Splenial Lesion Syndrome represents a distinct clinicoradiological syndrome, associated with several disorders, including infection, high altitude cerebral edema, antiepileptic drug withdrawal, and severe metabolic disturbances (hypoglycemia and hypernatremia). Clinical presentation is nonspecific, most frequently as an encephalopathy or encephalitis. Outcome is favorable in most patients unless there is a severe underlying disorder. Magnetic resonance imaging findings are restricted to the splenium and consist of a nonenhancing oval lesion, hyperintense on T2‐weighted images, including FLAIR. Findings on diffusion‐weighted imaging are consistent with cytotoxic edema except for high‐altitude cerebral edema, where vasogenic edema is present. Resolution after weeks or months is the rule. J Neuroimaging 2010;20:1‐2.