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Signal Changes in the Brain on Susceptibility‐Weighted Imaging Under Reduced Cerebral Blood Flow: A Preliminary Study
Author(s) -
Fushimi Yasutaka,
Miki Yukio,
Mori Nobuyuki,
Okada Tsutomu,
Urayama Shinichi,
Fukuyama Hidenao,
Togashi Kaori
Publication year - 2010
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/j.1552-6569.2008.00348.x
Subject(s) - cerebral blood flow , medicine , susceptibility weighted imaging , white matter , hyperventilation , nuclear medicine , frontal lobe , parenchyma , perfusion scanning , magnetic resonance imaging , cerebral perfusion pressure , perfusion , cardiology , radiology , pathology , psychiatry
OBJECTIVES To reveal the characteristics of susceptibility‐weighted imaging (SWI) under low cerebral blood flow (CBF) induced by hyperventilation (HV).MATERIALS AND METHODS This study was approved by the institutional review board. Informed consent was obtained. Six healthy volunteers (5 men, 1 woman; mean age, 29 years; range, 24‐33 years) underwent SWI and arterial spin labeling perfusion imaging under normal ventilation (NV) and HV at 3.0 T. Regions of interest (ROIs) were placed on gray matter (GM) and white matter (WM) of the frontal lobe (FL) and occipital lobe (OL). Intensities of ROIs were compared between NV and HV. Contrast of veins compared with adjacent cerebral parenchyma (CV) was also compared between NV and HV.RESULTS CBF during HV (CBF HV ) was decreased compared with CBF during NV (CBF NV ) (29.1 ± 4.6%). FL‐GM HV and OL‐GM HV showed significant signal decreases compared with FL‐GM NV and OL‐GM NV , respectively ( P = .018, .017). CV HV was significantly increased compared with CV NV (164.1 ± 29.9%) ( P = .00019).CONCLUSIONS SWI sensitively reflects HV‐induced decreases in CBF. The present results might assist in the interpretation of SWI in clinical practice, since CBF decreases might also influence signal changes on SWI.