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Proton Magnetic Resonance Spectroscopy Detects a Relative Decrease of N‐Acetylaspartate in the Hippocampus of Patients With Dementia With Lewy Bodies
Author(s) -
Xuan Xiaqing,
Ding Meiping,
Gong Xiangyang
Publication year - 2008
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/j.1552-6569.2007.00203.x
Subject(s) - hippocampus , dementia with lewy bodies , proton magnetic resonance , medicine , dementia , magnetic resonance imaging , lewy body , pathology , nuclear magnetic resonance , radiology , disease , physics
BACKGROUND AND PURPOSE To characterize the cerebral metabolic changes in dementia with Lewy bodies patients.METHODS The metabolic ratios of NAA/Cr and Cho/Cr in bilateral hippocampus were determined by proton magnetic resonance spectroscopy in 8 patients and 8 age‐matched healthy controls.RESULTS Dementia with Lewy bodies patients showed significantly lower NAA/Cr ratios in bilateral hippocampus, while the Cho/Cr ratio did not differ from the control group.CONCLUSIONS Our data show relatively decrease of N‐acetylaspartate in the hippocampus of patients with early or intermediate stage DLB. Hence, damage of neurons seems to be an early alteration in DLB.