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Intracranial Artery Calcification: A Newly Identified Risk Factor of Ischemic Stroke
Author(s) -
Chen Xiangyan,
Lam Wynnie Wai Man,
Ng Ho Keung,
Fan Yuhua,
Wong Ka Sing
Publication year - 2007
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/j.1552-6569.2007.00158.x
Subject(s) - medicine , calcification , cardiology , stroke (engine) , incidence (geometry) , risk factor , atrial fibrillation , hyperlipidemia , diabetes mellitus , radiology , optics , engineering , mechanical engineering , physics , endocrinology
ABSTRACT BACKGROUND AND PURPOSE Calcification in cerebral arteries is understudied, although frequently observed on computed tomography of the brain (CT brain). We aimed to assess the incidence of intracranial artery calcification in ischemic stroke patients and to evaluate its correlation with ischemic stroke.METHODS Our study included ischemic stroke patients and age‐gender‐matched nonischemic stroke patients referred for CT brain.RESULTS One hundred and seventy‐five ischemic stroke patients and 182 controls were enrolled. The highest prevalence of calcification was seen in intracranial internal carotid artery (IICA) (80.4%), and less commonly in the vertebral artery (35.6%). There was a higher prevalence of intracranial artery calcification in ischemic stroke patients than controls (92.6% vs. 76.4%, P < .001). Hypertension (OR = 2.056, 95% CI: 1.129 ∼ 3.745), diabetes (OR = 2.483, 95% CI: 1.233 ∼ 5.001), smoking (OR = 2.844, 95% CI: 1.542 ∼ 5.243), intracranial artery calcification (OR = 3.172, 95% CI: 1.252 ∼ 8.036), hyperlipidemia (OR = 6.714, 95% CI: 3.302 ∼ 13.650), and atrial fibrillation (OR = 7.941, 95% CI: 2.790 ∼ 22.599) were found to be independently associated with ischemic stroke.CONCLUSIONS We demonstrated a higher incidence of intracranial artery calcification in ischemic stroke patients. Besides traditional risk factors, intracranial artery calcification was found to be an independent risk factor of ischemic stroke.