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Thickening of Multiple Cranial Nerves in a Patient with Extranodal Peripheral T‐cell Lymphoma
Author(s) -
Matano Sadaya,
Shirasaki Hiroe,
Terahata Shintarou,
Nobata Koji,
Sugimoto Tatsuho
Publication year - 2006
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/j.1552-6569.2006.00028.x
Subject(s) - medicine , cranial nerves , peripheral t cell lymphoma , pathology , lymphoma , cd5 , diplopia , cerebrospinal fluid , dysarthria , chemotherapy , peripheral , magnetic resonance imaging , radiology , t cell , anatomy , surgery , immune system , immunology
ABSTRACT A 57‐year‐old male became aware of a subcutaneous tumor in March 2001. Histopathological examination showed peripheral T‐cell lymphoma. He achieved complete remission after chemotherapy. Later the lymphoma relapsed in the subcutaneous lesion and chemotherapy was performed again. In April 2003, he developed diplopia, dysarthria, and dysphagia. Abnormal lymphoid cells were found in the cerebrospinal fluid. An immunophenotypical study disclosed that CD2, CD3, CD5, and CD8 were positive. Rearrangement of TCR was detected by Southern blotting. Cranial magnetic resonance imaging did not detect any intraparenchymal lesions, but thickening of multiple cranial nerves was detected. These nerves were homogenously enhanced by gadolinium‐DTPA. After intrathecal chemotherapy, atypical cells disappeared from the cerebrospinal fluid and thickening of the cranial nerves was resolved. Finally, lymphoma spread to the bone marrow, and the patient died in July 2003.