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Progressive Cerebral Disease in Lymphomatoid Granulomatosis Causes Anterograde Amnesia and Neuropsychiatric Disorder
Author(s) -
Carone Dominic A.,
Benedict Ralph H. B.,
Zivadinov Robert,
Singh Baljinder,
Ambrus Julian L.
Publication year - 2006
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/j.1552-6569.2006.00019.x
Subject(s) - medicine , lymphomatoid granulomatosis , anterograde amnesia , disease , amnesia , dermatology , pathology , psychiatry , lymphoma
The authors report neuropsychological (NP) and serial quantitative magnetic resonance imaging (MRI) findings of a 29‐year‐old woman with lymphomatoid granulomatosis (LG). Disease course was characterized by acute psychosis, tremor, fever, seizures, and progressive cognitive impairment. At the time of symptom onset, brain MRI revealed mild lesion volume and normal parenchymal volume. This was followed by dramatic progression of brain lesions and atrophy over 2 years, at which point the patient expired. Atrophy was most prominent in the mesial temporal lobes. NP testing revealed marked amnesia and mild impairments in other cognitive domains. To our knowledge, this is the first recorded case of LG in which bilateral temporal lobe atrophy is evident and accompanied by anterograde amnesia. We speculate that temporal lobe atrophy was influenced by the established susceptibility of this region in various neurological diseases.