Premium
Unsuccessful Tissue Plasminogen Activator Treatment of Acute Stroke Caused by a Calcific Embolus
Author(s) -
Halloran John I.,
Bekavac Ivo
Publication year - 2004
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/j.1552-6569.2004.tb00270.x
Subject(s) - medicine , embolus , intracranial embolism , tissue plasminogen activator , stroke (engine) , calcification , ischemia , thrombolysis , acute stroke , plasminogen activator , embolism , surgery , myocardial infarction , mechanical engineering , engineering
Intravenous (IV) administration of tissue plasminogen activator (tPA) given to patients during acute cerebral ischemia according to National Institute of Neurological Disorders and Stroke (NINDS) guidelines improves clinical outcome by 11% to 14%. The success of IV tPA stroke therapy is dependent on several previously reported factors. The authors suggest that the presence of calcification within an embolus may represent an additional important factor. This report describes a patient with an acute stroke secondary to a spontaneous calcific cerebral embolus who had a negative outcome despite receiving proper thrombolytic therapy.