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Anatomical Functional Changes in a Patient Presenting a Complex Malformation of Cortical Development
Author(s) -
Calistri Valentina,
Lenzi Delia,
Gilio Francesca,
Bonaventura Carlo,
Inghilleri Maurizio,
Mainero Caterina,
Pantano Patrizia
Publication year - 2004
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/j.1552-6569.2004.tb00269.x
Subject(s) - schizencephaly , medicine , functional magnetic resonance imaging , corpus callosum , neuroscience , agenesis of the corpus callosum , motor cortex , supplementary motor area , cortex (anatomy) , anatomy , magnetic resonance imaging , thumb , posterior parietal cortex , psychology , radiology , stimulation
The authors describe a case of right fronto‐parietal micropoligyria associated with small schizencephaly clefts and the presence of a frontal open‐lip schizencephaly with corpus callosum agenesis. A functional magnetic resonance imaging (fMRI) study was performed to evaluate the possible reorganization of cortical functions in a patient presentinga complex malformation pattern and to investigate which cortical areas were activated during left finger movements. An fMRI study was performed during the execution of a repetitive index finger‐to‐thumb opposition movement with the right hand and the left hand in 2 separate sessions. Movement of the right hand induced a normal motor activation pattern involving the contralateral left sensory‐motor cortex. Movement of the left hand produced significant activation of brain cortex. This fMRI study highlights the compensatory role of the ipsilateral cortical pathways in hand movements in the case of a complex brain malformation that involves the main motor activation areas.