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Contralateral Cerebral Blood Flow Velocity Changes after Intracarotid Amobarbital Injection
Author(s) -
Pfefferkorn T.,
Hundt C.,
Arnold S.,
Missler U.,
Noachtar S.,
Hamann G. F.
Publication year - 2004
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/j.1552-6569.2004.tb00263.x
Subject(s) - medicine , amobarbital , anesthesia , middle cerebral artery , epilepsy , perfusion , cerebral blood flow , transcranial doppler , blood flow , cardiology , ischemia , psychiatry
Background and Purpose . The intracarotid amobarbital procedure (IAP) leads to a prompt decrease in ipsilateral middle cere bral artery (MCA) mean blood flow velocity (MFV). Little is known about contralateral MFV changes. Methods . The authors investigated bilateral MCA MFV using transcranial Doppler sonography (TCD) in 8 patients with epilepsy undergoing IAP. Measurements were excluded from analysis if angiography revealed any signs of interhemispheric cross‐flow. Results . With in 64 seconds after amobarbital injection, ipsilateral MFV decreased to a mean of 44.4%± 7.5% of baseline value ( P < .01). In the absence of interhemispheric cross‐flow and within 68 seconds, contralateral MFV decreased to 83.1%± 7.9% ( P < .01). Conclusions . The observed decrease of contralateral MFV was not caused by amobarbital cross‐perfusion. A possible underlying mechanism may be interhemispheric deafferentation.