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Cerebrovascular Reactivity in Hypertensive and Healthy Adolescents: TCD With Vasodilatory Challenge
Author(s) -
Settakis Georgios,
Páll Dénes,
Molnár Csilla,
Bereczki Dániel,
Csiba László,
Fülesdi Béla
Publication year - 2003
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/j.1552-6569.2003.tb00166.x
Subject(s) - medicine , transcranial doppler , vasodilation , cardiology , diastole , blood pressure , blood flow , cerebral blood flow , population , anesthesia , environmental health
Background . Adolescent hypertension predicts hypertension and increased cardiovascular morbidity in adulthood. The aim of the present work was to test whether cerebrovascular reactivity to CO 2 is altered among hypertensive adolescents. Methods . From the population‐based cohort of the Debrecen Hypertension Study, 113 hypertensive and 58 normotensive adolescents underwent transcranial Doppler measurements at rest and after 30 seconds of breath holding. Results . Systolic, mean, and diastolic blood flow velocities were higher among hypertensive individuals at rest. Taking the absolute blood flow velocity parameters into account, after breath holding, only the pulsatility index was significantly higher in the hypertensive group. The percentage change of the different blood flow parameters showed less intensive change in hypertensive teenagers. Conclusion . Cerebral vasoreactivity is decreased among hypertensive individuals as compared to healthy controls.