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Susceptibility Contrast and Arterial Spin Labeled Perfusion MRI in Cerebrovascular Disease
Author(s) -
Wolf Ronald L.,
Alsop David C.,
McGarvey Michael L.,
Maldjian Joseph A.,
Wang Jiongjiong,
Detre John A.
Publication year - 2003
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/j.1552-6569.2003.tb00152.x
Subject(s) - perfusion , medicine , cerebral blood flow , mean transit time , perfusion scanning , magnetic resonance imaging , contrast (vision) , arterial spin labeling , nuclear medicine , radiology , cerebral blood volume , cardiology , computer science , artificial intelligence
Purpose . To directly compare dynamic susceptibility contrast (DSC) and continuous arterial spin labeled (CASL) magnetic resonance (MR) perfusion techniques in patients with known cerebrovascular disease, with the goals of identifying possible pitfalls in interpretation and determining potential for a complementary role in this setting. Methods . DSC and CASL MR perfusion studies were performed and compared in 11 patients with acute and/or chronic cerebrovascular disease. Using an automated segmentation technique, Pearson correlation coefficients were generated for CASL perfusion measurements compared to DSC perfusion maps (time‐to‐peak [TTP], relative cerebral blood volume [rCBV], cerebral blood flow [rCBF], and mean transit time [MTT]) by hemisphere and vascular territory. Results . TTP maps obtained using DSC perfusion MR correlated best both subjectively and objectively with CASL perfusion MRmeasurements when all patients studied were considered. If patients with a major transit delay were excluded, DSC rCBF correlated best with CASL CBF measurements. Conclusion . There may be a complementary role for CASL and DSC perfusion MR methods in cerebrovascular disease, especially in the setting of a marked transit delay.