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Elevated Basal Ganglia Glucose Metabolism in Cyclosporine Neurotoxicity: A Positron Emission Tomography Imaging Study
Author(s) -
Meyer Michael Andrew
Publication year - 2002
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/j.1552-6569.2002.tb00102.x
Subject(s) - medicine , positron emission tomography , neurotoxicity , basal ganglia , fluorodeoxyglucose , basal (medicine) , pathophysiology , bone marrow transplant , bone marrow , metabolic activity , pet imaging , nuclear medicine , basal metabolic rate , toxicity , central nervous system , endocrinology , physiology , bone marrow transplantation , diabetes mellitus
Abnormally increased 18F‐fluorodeoxyglucose uptake in the basal ganglia was noted by positron emission tomography (PET) in a 37‐year‐old bone marrow transplant patient who had severe intention tremors of his hands and a progressive psychiatric change with social withdrawal and flat affect. This is the first PET report on metabolic abnormalities in cyclosporine neurotoxicity. It emphasizes the need for more research to understand the pathophysiology of these changes.