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HIV‐2 Infection With Cerebral Toxoplasmosis and Lymphomatoid Granulomatosis
Author(s) -
Issakhanian M.,
Chang L.,
Cornford M.,
Witt M.,
Speck O.,
Goldberg M.,
Ernst T.
Publication year - 2001
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/j.1552-6569.2001.tb00037.x
Subject(s) - medicine , toxoplasmosis , pathology , lymphomatoid granulomatosis , serology , magnetic resonance imaging , neuropathology , progressive multifocal leukoencephalopathy , brain biopsy , pathological , hyperintensity , human immunodeficiency virus (hiv) , lesion , biopsy , multiple sclerosis , radiology , immunology , lymphoma , antibody , disease
A Nigerian man had acute onset of headache and vertigo due to a cerebellar mass. A brain biopsy of the mass revealed toxoplasmosis despite repeated negative HIV‐1 serology. The presence of an opportunistic infection and his country of origin raised the suspicion for HIV‐2; this was confirmed by positive HIV‐2 serology. Despite his preliminary pathological diagnosis, results of physiological magnetic resonance imaging (MRI) (perfusion MRI and proton magnetic resonance spectroscopy) were not typical for toxoplasmosis. The lesion showed a biochemical and perfusion pattern that was intermediate for infectious and neoplastic processes. Further neuropathology confirmed a secondary diagnosis of lymphomatoid granulomatosis.