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Effect of Hyperventilation on Cerebral Blood Flow Velocity in Preeclamptic Pregnancies: Is There Evidence for an Altered Cerebral Vasoreactivity?
Author(s) -
Zatik J.,
Aranyosi J.,
Molnár C.,
Páll D.,
Borsos A.,
Fülesdi B.
Publication year - 2001
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/j.1552-6569.2001.tb00030.x
Subject(s) - medicine , middle cerebral artery , hyperventilation , cerebral blood flow , vasoconstriction , cerebral arteries , transcranial doppler , preeclampsia , cardiology , blood flow , vasodilation , cerebral circulation , anesthesia , pregnancy , ischemia , biology , genetics
The purpose of this study was to investigate cerebral arteriolar vasoreactivity function in preeclampsia. Preeclamptic ( n = 26) and healthy pregnant ( n = 22) women underwent transcranial Doppler sonography of the middle cerebral artery at rest and after 60 seconds of hyperventilation (HV). Systolic, diastolic, and mean blood flow velocities were recorded. The percentage change of the blood flow velocities after HV was calculated. Mean blood flow velocity of the middle cerebral artery was higher in preeclamptic women as compared with healthy pregnant women. No difference could be detected in percentage change of middle cerebral artery blood flow velocities after HV between the two groups. There is no evidence of a small‐vessel vasoconstriction among preeclamptic patients. The role of vasoconstriction of the large cerebral arteries and vasodilation of the resistance arterioles, as well as a combination of these 2 pathomechanisms, in determining cerebral blood flow in preeclampsia and eclampsia should be investigated in further studies.