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Effect of Thermal Treatment of Sol‐Gel Titania Reservoirs on Release Kinetics of Phenytoin
Author(s) -
Kozina Anna,
Espinoza Karla A.,
OrtizIslas Emma,
Rivero Ignacio A.
Publication year - 2012
Publication title -
journal of the american ceramic society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 196
eISSN - 1551-2916
pISSN - 0002-7820
DOI - 10.1111/j.1551-2916.2012.05190.x
Subject(s) - phenytoin , kinetics , thermal stability , chemistry , melting point , chemical engineering , matrix (chemical analysis) , materials science , drug , chromatography , composite material , pharmacology , organic chemistry , epilepsy , medicine , physics , quantum mechanics , neuroscience , engineering , biology
The thermal stability of antiepileptic drug phenytoin was investigated on its encapsulation in titania matrix. It was shown that the drug is stable up to 150°C, even though phenytoin melting point was previously reported to be much higher. The mechanism of phenytoin decomposition is suggested and confirmed by the experiment on heating to higher temperatures. The influence of thermal treatment on physicochemical parameters of the matrix was studied. Quite different drug release kinetics were obtained in vitro and discussed in terms of temperature treatment influence and interplay of parameters of the matrix.